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KMID : 0359920060250050753
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Korean Journal of Nephrology
2006 Volume.25 No. 5 p.753 ~ p.759
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The Polymorphisms of PPAR-γ Coactivator 1α Gly482Ser (PGC-1α Gly482Ser) are Associated with the Nephropathy of Korean Patients with Type 2 Diabetes Mellitus
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Jung Lae-Ik
Suh Jung-Ho
Kim Mi-A
Chung Kyung-Hwan
Moon Ju-Young
Lee Sang-Ho
Lee Tae-Won
Ihm Chun-Gyoo
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Abstract
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Background : We investigated the effects of the common polymorphisms in the peroxisome proliferatoractivated receptor γ2 (PPAR-γ2 Pro12Ala) and in PPAR-γ coactivator 1α (PGC-1α Gly482Ser) genes on the association with the nephropathy of Korean patients with type 2 diabetes mellitus.
Methods : A total of 113 patients with type 2 diabetes and 123 patients with diabetic nephropathy were enrolled in this study. The Pro12Ala polymorphism of the PPAR-γ2 gene and the Gly482Ser polymorphism in the PGC-1α gene were determined with the polymerase chain reaction amplification, BstU-I and Msp I enzyme digestion, and gel electrophoresis.
Results : The genotype and allelic frequency of PPAR-γ2 Pro12Ala gene were not different statistically between the diabetic nephropathy and the control. The genotype of PGC-1α Gly482Ser in diabetic nephropathy was also not different from those in control. The allelic frequency and carriage rate of Ser allele in PGC-1α Gly482Ser were significantly higher in patients with diabetic nephropathy than those in control (respectively, p<0.05).
Conclusion : The polymorphisms of the PGC-1α Gly482Ser gene are significantly associated with the nephropathy in Korean patients with type 2 diabetes mellitus. (Korean J Nephrol 2006;25(5):753-759)
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KEYWORD
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Diabetic nephropathy, Polymorphism, Peroxisome proliferator-activated receptor γ, PPAR-γ coactivator 1α
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